Seems like every week over on GamingOnLinux there’s an announcement of a new launcher.
Personally I only use Steam & Lutris. Lutris for my gog games and BattleNet, Steam for everything else.
I don’t know of a good reason to use Heroic, or any of the other new ones over Lutris / Steam, but maybe I’m missing out.
I use Steam for probably 80% of the games that I play regularly,
PrismLauncher for Minecraft (modded and vanilla java),
Heroic for gog and Epic,
Lutris for BattleNet (as well as the original non-“Resurrected” Diablo 2), Amazon Games App (free twitch/prime gaming games), EA App (got a few free games through EA Origin several years back), Ubisoft Connect, and the launcher version of Minecraft Dungeons. I’ve always found the lutris interface a little clunky and unintuitive, but games and things will usually work okay if I can get them installed (which will often take me a few failed attempts before I work it out).
and finally the official itch.io app is really very good, lets you choose native linux versions of games that have 'em, as well as rather seamlessly making wine prefixes for windows versions of games.
I did also used to use EmulationStation Desktop Edition as a front-end for a few different emulators, but it seems I didn’t reinstall it when I did my latest OS reinstall a few months ago, I guess I’ve just been playing a lot more newer games (or just running retroarch without es-de).