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  • cheese_greater@lemmy.worldOP
    2·
    11 months ago

    Thanks and I will check those out. Does the flumazenil displace GABA_B ligands/receptors as well or only _A?

    Thats all for tonight, night

      • cheese_greater@lemmy.worldOP
        2·
        11 months ago

        It seems as if _B ligands are both way less ubiquitous and also variably less-reinforcing than traditional alcohol-type sedatives like benzos/barbs/sleeps, although I say that very conjecturally (is that a word? Aha). And less likely to be overdone to the point the therapeutic window is being dangerously exceeded or a polypharmacy situation that leads to medical emergency like that

        From my own experience with baclofen which I used to wean off drinking and help with the induced anxiety, I didn’t really find it super pleasent or enjoyable and there were enough annoying sides like tearing up and a crappy fuzziness that was super offputting. Alcohol and sedatives (especially sleeping pills), totes different story (I find them as a class GABA_A way more dangerous and mindlessly compulsive.

        • Chetzemoka@startrek.website
          2·
          11 months ago

          Huh, now that’s super interesting.

          Ok you and I both have to go to sleep, but now you’ve got me wondering about the eternal debate amongst our medical residents about benzos vs. barbiturates for acute alcohol withdrawal. I’ll have to read up on this some more

          • cheese_greater@lemmy.worldOP
            1·
            11 months ago

            Yeah, ask about baclofen, its famously advocated by a French dr who struggled to find a proper treatment for his alcoholism until he arrived on baclofen. End of My Addiction is the title.

            I used it as an adjuvant treatment along with naltrexone and careful timing in terms of the actual drinking that was required to make the naltrexone effective in addressing the neurochemical basis for much of the compulsion from alcohol.